Introduction To Pharmacokinetics

Absorption Rate Constant

HOW TO FIND THE ABSORPTION RATE CONSTANT

To find the absorption rate constant:
  • Using a semilogarithmic plot of the concentration-time curve, apply the method of residuals to find out if absorption is a first order process.
    (If absorption is a first order process, the residuals graph will be a straight line.)
  • If absorption is a first order process, use the residuals graph to find the absorption half-life (t1/2(a)).
  • Once you have the absorption half-life, use the equation below to calculate the absorption rate constant.
    Equation

The next two pages go through the method.