Pharmacokinetics Simulations

One Compartment Model: Single IV Bolus Dose

INSTRUCTIONS

On the following page, you can simulate results for what happens to the plasma drug concentration of a drug over time for a one compartment model when a single IV bolus dose is given.

You need to:

  • Select whether to plot the results on a linear scale or semilog scale. The scale is preset to linear. (You can change between the two at any time: all current results will be replotted on the new scale.)
  • Adjust the dose (D), volume of distribution (Vd) and elimination rate constant (k). These are all preset.
  • Adjust the x-axis and y-axis scales if required. (These can be adjusted at any time: all current results will be replotted on the new axes.)
  • Plot the results - up to a maximum of six plots.

You can reset the simulation at any time: the simulation will return to the initial preset values.