INTRODUCTION
This activity covers the following:
- What total body clearance (clearance) is
- The units and symbol for clearance
- A simulation in which you can see the effect of changing the value of clearance
- Why it is useful to know clearance
- How to find clearance - showing the range of equations available
(including equations using the elimination rate constant, AUC and the steady state concentration)
Before you start
You need to know what area under the concentration-time curve (AUC) is and how to find it.