Introduction To Pharmacokinetics
Total Body Clearance
The simulation plots how concentration of an example drug changes over time. Change the elimination rate constant and volume of distribution to see how this affects clearance.
(Assume all other parameters remain the same.)
(Assume all other parameters remain the same.)
Linear Scale
Semilog Scale
Remember:
Volume Of Distribution (Vd) (0 - 200 L)
L
L
Elimination Rate Constant (k) (0 - 3 h-1)
h-1
h-1
Set x-axis (h):
0-12
0-24
0-36
Set y-axis (mg/L): 0-10 0-100 0-1000
Set y-axis (mg/L): 0-10 0-100 0-1000