Miscellaneous Agents
Inevitably there are some chemotherapeutic agents
that do not fit into this classification. For example:
Bleomycin- Cristanaspase
- Procarbazine and Hydroxycarbamide/Hydroxyurea
Bleomycin
Bleomycin exerts its effect during the G2 phase.
Cristanaspase
Cristanaspase exerts its effect during the G1 phase.
The M Phase
M = Mitosis
During the M phase, the cell undergoes cell division. Cell division consists of nuclear division (mitosis) and cytoplasmic division (cytokinesis). The M phase ends on completion of cell division.
Nuclear Division: At the start of the M phase, the cell contains double the amount of nuclear DNA and the chromosomes each consist of two sister chromatids. During mitosis, the cell divides into two daughter cells and one chromatid from each chromosome goes into each daughter cell.
The G2 Phase
G = Growth
The G2 phase is the later growth phase.
The S Phase
The S phase is the phase in which DNA is synthesised. The phase starts when DNA synthesis starts and ends when the amount of nuclear DNA has doubled and the chromosomes have replicated. At the end of the S phase, each chromosome will consist of two sister chromatids.
The G1 Phase
G = Growth
The G1 phase is the early growth phase. During mitosis, biosynthetic activities of the cell becomes very slow. In the G1 phase, these activities resume at a high rate.
The G0 Phase
G = Growth
A newly divided cell may re-enter the cell cycle, or it may enter the G0 phase which is a resting, non-proliferative phase.
M = Mitosis
G0 = Resting Phase
G1 = Early Growth Phase
S = DNA Synthesis
G2 = Later Growth Phase
Procarbazine...
Procarbazine and hydroxycarbamide/hydroxyurea are miscellaneous cell cycle nonspecific agents.