Pharmacokinetics Simulations

Two Compartment Model: Single IV Bolus Dose

INTRODUCTION

This simulation is for a single IV bolus dose - for a two compartment model. The model system is NOT at steady state.

Page 2 shows the pharmacokinetic model for this simulation (also available by clicking on the option at the bottom left called "Pharmacokinetic Model"). The equations used are also available - click on "Equations" at the bottom left.

Page 3 provides instructions for the simulation and page 4 covers the simulation itself. In the simulation you can see how changes in the following affect plasma drug concentration levels over time:

dose (D)
volume of distribution of the central compartment (Vc)
first order transfer rate constant from the central to the peripheral compartment (k12)
first order transfer rate constant from the peripheral to the central compartment (k21)
first order elimination rate constant from the central compartment (k10)

The results can be plotted either on a linear scale or on a semilog scale.