Calculating the Sample Concentration
The sample concentration will be calculated against a reference standard of known concentration. The result in % label claim will be compared to acceptable ranges stated in the dissolution method or monograph.
The following calculation provides results in % label claim (%LC).
Move the cursor over the blue elements of the calculation for a description.
Once analyzed, dissolution samples are calculated to determine the amount dissolved (mg) and/or the percent of the labeled amount of active drug substance dissolved in solution.
Analyzed Profiles
- Dissolution Results Percent Label Claim (%LC)
- =
- x
- x
- x
- 100
Sample Abs.
Sample response, UV Absorbance or HPLC integrated value
Sample response, UV Absorbance or HPLC integrated value
Standard Abs.
Standard response, UV Absorbance
or HPLC integrated value
Standard response, UV Absorbance
or HPLC integrated value
Standard Wt. (mg)
Accurate weight of the
reference standard in mg
Accurate weight of the
reference standard in mg
Standard Vol. (mL)
The volume of diluent in which the
standard was dissolved. The standard
may require additional dilution [mL/mL].
The volume of diluent in which the
standard was dissolved. The standard
may require additional dilution [mL/mL].
Sample Vol. (mL)
Dissolution Sample volume,
typically 500 mL or 900 mL
Dissolution Sample volume,
typically 500 mL or 900 mL
Label Claim (mg)
The amount of active drug (mg)
contained in each dosage unit
The amount of active drug (mg)
contained in each dosage unit