Introduction To Pharmacokinetics
The Trapezoidal Rule
AREA TO INFINITY CONTINUED
For the example graph, the last time point was at 12 hours and the concentration recorded at that time was 0.9 mg/L.
The rate constant for the final part of the curve is 0.25 h-1.
Using the equation:
The area of the extrapolated part of the curve is:
Extrapolated area = 0.9 / 0.25 mgxh/L
Extrapolated area = 3.6 mgxh/L