Pharmacokinetics Simulations

Single Oral Dose - Changing Bioavailability

OBSERVATIONS

Higher drug bioavailability results in higher plasma concentrations.

As drug bioavailability increases, the peak plasma drug concentration also increases.

However, the time at which the peak plasma concentration is reached remains the same: the time is not affected by changes in bioavailability.

Similarly, the rate of decrease of plasma drug concentration remains the same: the rate of decrease is not affected by changes in bioavailability.

Changes In Bioavailability