Introduction To Pharmacokinetics

Short IV Infusion - Summary

A patient is given a single short intravenous infusion of 700 mg of a drug over a period of 7 hours, after which the infusion is stopped. The concentration-time data is collected.

SUMMARY

You have finished calculating the parameters.

Using information from the graph across, you were able to calculate the following parameters:

t1/2 = 0.5 hours

k = 1.386 h-1

CSS = 4.0 mg

CL = 25.0 L/h

Vd = 18.0 L

Click here to have a final quick look at
the methods and equations used.

Time (h)	Plasma Drug Concentration (mg/L)
0	0.0
0.5	2.0
1	3.0
1.5	3.6
2	3.8
3	3.9
4	4.0
5	4.0
6	4.0
7	4.0
7.5	2.0
8	1.0
8.5	0.5
9	0.25
9.5	0.13