Introduction To Pharmacokinetics

Single Short IV Infusion - CL

A patient is given a single short IV infusion of 700 mg of a drug over a period of 7 hours.

You now know the following:
t1/2 = 0.5 hours k = 1.386 h-1
Css = 4.0 mg

What is the clearance of the drug?

Type in your answer to one decimal place then press the OK button.

The clearance is: L/h

Time (h)	Plasma Drug Concentration (mg/L)
0	0.0
0.5	2.0
1	3.0
1.5	3.6
2	3.8
3	3.9
4	4.0
5	4.0
6	4.0
7	4.0
7.5	2.0
8	1.0
8.5	0.5
9	0.25
9.5	0.13