A patient is given a single short intravenous infusion of 700 mg of a drug over a period of 7 hours, after which the infusion is stopped. The concentration-time data is collected.

When the concentration-time data is plotted, you see the semilogarithmic graph across. You will use this graph to calculate pharmacokinetic parameters.

The first pharmacokinetic parameter you will find is the elimination half-life (t1/2).

Once you know the elimination half-life, you can then go on to calculate the elimination rate constant (k) and find the steady state concentration.

Have a look at the concentration-time data and then turn to the next page.