Introduction To Pharmacokinetics
Single Short IV Infusion Exercise
PLASMA DRUG CONCENTRATION EQUATION
At any time, the plasma drug concentration following administration by a single short IV infusion is given by the equations below. Once you have found the parameters you can use these equations to calculate the plasma drug concentration at time t.
Concentration during infusion: Concentration once infusion stopped:
Dose = 700 mg
TInf = 7 h
(duration of infusion)
t1/2 = 0.5 hoursk = 1.386 h-1
CSS = 4.0 mg
CL = 25.0 L/h
Vd = 18.0 L
Example Question: What was the plasma concentration at 45 minutes?
Type in your answer to two decimal places then press the OK button.
The plasma concentration was:
mg/L