Introduction To Pharmacokinetics

Oral Dosing - Introduction

The remaining values of C*-C have been calculated for you. The values of C*-C have then been plotted on the same axes as the concentration-time curve and the best fit line drawn - this is the residuals graph, drawn in red.

Looking at the residuals graph, you can see that it forms a straight line. This tells you that absorption IS a first order process.

You can therefore use the residuals graph to find the absorption half-life, and from this, the absorption rate constant.

Turn to the next page to find the absorption half-life.

Time (h) Plasma Drug Concentration (mg/L)C* (mg/L)C*-C (mg/L)
008.28.2
0.52.56.64.1
13.25.42.2
1.53.14.21.1
22.83.30.5
32.02.10.1
41.31.30
50.80.80
60.50.50
70.30.30
80.20.20