Introduction To Pharmacokinetics

Oral Dosing - CL

A patient is given a 500 mg dose of a drug via a single oral dose.
You now know the following:
F = 0.45        t1/2 = 1.5 hours         k = 0.462 h-1
AUC = 11.933 mgxh/L
What is the clearance of the drug?
Type in your answer to two decimal places then press the OK button.
The clearance is:   L/h
Hint/Equation
Time (h) Plasma Drug Concentration (mg/L)
00
0.52.5
13.2
1.53.1
22.8
32.0
41.3
50.8
60.5
70.3
80.2
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