Introduction To Pharmacokinetics

Oral Dosing - Summary

A patient is given a 500 mg dose of a drug via a single oral dose and the concentration- time data is collected.

SUMMARY

You have finished calculating the parameters.

Using information from the graph across, you were able to calculate the following parameters:

t1/2 = 1.5 hours
k = 0.462 h-1
AUC = 11.933 mgxh/L
CL = 18.86 L/h
Vd = 40.8 L
t1/2(a) = 0.5 hours
ka = 1.368 h-1

Click here to have a final quick look at
the methods and equations used.

Time (h) Plasma Drug Concentration (mg/L)
00
0.52.5
13.2
1.53.1
22.8
32.0
41.3
50.8
60.5
70.3
80.2
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