Introduction To Pharmacokinetics
Oral Dosing Exercise
PLASMA DRUG CONCENTRATION EQUATION
At any time, the plasma drug concentration following administration by a single oral dose is given by the equation below. Once you have found the parameters you can use this equation to calculate the plasma drug concentration at time t.
Dose = 500 mg
F = 0.45
t1/2 = 1.5 hours
k = 0.462 h-1
t1/2(a) = 0.5 hours
ka = 1.368 h-1
AUC = 11.933 mgxh/L
CL = 18.86 L/h
Vd = 40.8 L
Example Question: What was the plasma concentration at 2.5 hours?
Type in your answer to two decimal places then press the OK button.
The plasma concentration was:
mg/L