Oral Dosing - Introduction
A patient is given a 500 mg dose of a drug via a single oral dose and the concentration- time data is collected.
When the concentration-time data is plotted, you see the semilogarithmic graph across. You will use this graph to calculate pharmacokinetic parameters.
The following is already known about the drug:
Bioavailability (F) = 0.45
The first pharmacokinetic parameter you will find is the elimination half-life (t1/2).
Once you know the elimination half-life, you can then go on to calculate the elimination rate constant (k).
Have a look at the concentration-time data and then turn to the next page.
